Home Carbonyls Pyridinium, 3-(aminocarbonyl)-1-methyl-, chloride (1:1)

Pyridinium, 3-(aminocarbonyl)-1-methyl-, chloride (1:1)

CAS No.:
1005-24-9
Catalog Number:
AG00025R
Molecular Formula:
C7H9ClN2O
Molecular Weight:
172.6122

SDS

Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
98%
in stock
China
$46
- +
5g
98%
in stock
China
$155
- +
25g
98%
in stock
China
$476
- +
Product Description
Catalog Number:
AG00025R
Chemical Name:
Pyridinium, 3-(aminocarbonyl)-1-methyl-, chloride (1:1)
CAS Number:
1005-24-9
Molecular Formula:
C7H9ClN2O
Molecular Weight:
172.6122
MDL Number:
MFCD00060042
IUPAC Name:
1-methylpyridin-1-ium-3-carboxamide;chloride
InChI:
InChI=1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H
InChI Key:
BWVDQVQUNNBTLK-UHFFFAOYSA-N
SMILES:
C[n+]1cccc(c1)C(=O)N.[Cl-]
EC Number:
463-670-7
UNII:
L54XNJ1D5G
Properties
Complexity:
136  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
172.04g/mol
Formal Charge:
0
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
172.612g/mol
Monoisotopic Mass:
172.04g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
47A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
N-Methyl-2-pyridone-5-carboxamide is 1-methylnicotinamide metabolite of low cyclooxygenase-dependent vasodilating activity. Journal of physiology and biochemistry 20120901
Toxic effects of nicotinamide methylation on mouse brain striatum neuronal cells and its relation to manganese. Environmental health and preventive medicine 20120901
Excess nicotinamide inhibits methylation-mediated degradation of catecholamines in normotensives and hypertensives. Hypertension research : official journal of the Japanese Society of Hypertension 20120201
Effects of N1-methylnicotinamide on oxidative and glycooxidative stress markers in rats with streptozotocin-induced diabetes mellitus. Redox report : communications in free radical research 20120101
Developmental changes of aldehyde oxidase activity and protein expression in human liver cytosol. Drug metabolism and pharmacokinetics 20120101
Decreased skin-mediated detoxification contributes to oxidative stress and insulin resistance. Experimental diabetes research 20120101
The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors. The Biochemical journal 20110515
¹H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure. Clinical biochemistry 20110301
Effect of tea beverages on aldehyde oxidase activity. Drug metabolism and pharmacokinetics 20110101
Effects of 1-methylnicotinamide and its metabolite N-methyl-2-pyridone-5-carboxamide on streptozotocin-induced toxicity in murine insulinoma MIN6 cell line. Acta biochimica Polonica 20110101
Effect of selected NAD+ analogues on mitochondria activity and proliferation of endothelial EA.hy926 cells. European journal of pharmacology 20100825
1-methylnicotinamide effects on the selected markers of endothelial function, inflammation and haemostasis in diabetic rats. European journal of pharmacology 20100825
3-D-QSAR and docking studies on the neuronal choline transporter. Bioorganic & medicinal chemistry letters 20100815
[Effect of 1-methylnicotinamide on prooxidant-antioxidant balance parameters in rats during hepatic ischemia-reperfusion]. Eksperimental'naia i klinicheskaia farmakologiia 20100401
1-methylnicotinamide (MNA) in prevention of diabetes-associated brain disorders. Neurochemistry international 20100101
Nicotinamide N-methyltransferase (NNMT) and 1-methylnicotinamide (MNA) in experimental hepatitis induced by concanavalin A in the mouse. Pharmacological reports : PR 20100101
Effect of nicotinamide and its two derivatives on the generation of reactive oxygen species in human monocytes cooperating with platelets. Acta poloniae pharmaceutica 20100101
Nicotinamide overload may play a role in the development of type 2 diabetes. World journal of gastroenterology 20091207
Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine. Atherosclerosis 20090601
Activation of nicotinamide N-methyltrasferase and increased formation of 1-methylnicotinamide (MNA) in atherosclerosis. Pharmacological reports : PR 20090101
Anti-diabetic effects of 1-methylnicotinamide (MNA) in streptozocin-induced diabetes in rats. Pharmacological reports : PR 20090101
Matrix metaloproteinases activity during the evolution of hypoxic-ischemic brain damage in the immature rat. The effect of 1-methylnicotinamide (MNA). Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20080901
Aldehyde oxidase-catalyzed metabolism of N1-methylnicotinamide in vivo and in vitro in chimeric mice with humanized liver. Drug metabolism and disposition: the biological fate of chemicals 20080701
Therapeutic potential of 1-methylnicotinamide against acute gastric lesions induced by stress: role of endogenous prostacyclin and sensory nerves. The Journal of pharmacology and experimental therapeutics 20080701
1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages. Archivum immunologiae et therapiae experimentalis 20080401
Anti-inflammatory effect of 1-methylnicotinamide in contact hypersensitivity to oxazolone in mice; involvement of prostacyclin. European journal of pharmacology 20080114
1-Methylnicotinamide (MNA) prevents endothelial dysfunction in hypertriglyceridemic and diabetic rats. Pharmacological reports : PR 20080101
Neuroprotective effects of nicotinamide and 1-methylnicotinamide in acute excitotoxicity in vitro. Folia neuropathologica 20080101
Nicotinamide and 1-methylnicotinamide reduce homocysteine neurotoxicity in primary cultures of rat cerebellar granule cells. Acta neurobiologiae experimentalis 20080101
1-Methylnicotinamide stimulates cell growth and inhibits hemoglobin synthesis in differentiating murine erythroleukemia cells. Toxicology in vitro : an international journal published in association with BIBRA 20071201
1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway. British journal of pharmacology 20070901
Developmental changes of aldehyde oxidase in postnatal rat liver. Drug metabolism and pharmacokinetics 20070401
Metabolites of the radiosensitizer nicotinamide are unlikely to contribute to the degree of emesis observed with the parent drug. Oncology research 20070101
Spectrofluorimetric determination of drugs containing active methylene group using N1-methyl nicotinamide chloride as a fluorigenic agent. Chemical & pharmaceutical bulletin 20060701
Estimation of aldehyde oxidase activity in vivo from conversion ratio of N1-methylnicotinamide to pyridones, and intraspecies variation of the enzyme activity in rats. Drug metabolism and disposition: the biological fate of chemicals 20060201
Search for drugs of the combined anti-inflammatory and anti-bacterial properties: 1-methyl-N'-(hydroxymethyl)nicotinamide. Pharmacological reports : PR 20060101
[The effect of magnesium pool isotopy on reactivation of mitochondrial ATP synthesis suppressed by 1-methyl-nicotine amide]. Biomeditsinskaia khimiia 20060101
Topical application of 1-methylnicotinamide in the treatment of rosacea: a pilot study. Clinical and experimental dermatology 20051101
Quantitation of the niacin metabolites 1-methylnicotinamide and l-methyl-2-pyridone-5-carboxamide in random spot urine samples, by ion-pairing reverse-phase HPLC with UV detection, and the implications for the use of spot urine samples in the assessment of niacin status. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050325
Spectrofluorimetric determination of warfarin sodium by using N1-methylnicotinamide chloride as a fluorigenic agent. Journal of AOAC International 20050101
1-Methylnicotinamide: a potent anti-inflammatory agent of vitamin origin. Polish journal of pharmacology 20030101
Potential urinary and plasma biomarkers of peroxisome proliferation in the rat: identification of N-methylnicotinamide and N-methyl-4-pyridone-3-carboxamide by 1H nuclear magnetic resonance and high performance liquid chromatography. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20030101
[Elucidation of paraquat poisoning mechanism and development of the neuronal death model]. Nihon eiseigaku zasshi. Japanese journal of hygiene 20020401
Possible role of 1-methylnicotinamide in the pathogenesis of Parkinson's disease. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20020201
Rapid calmodulin-dependent interdomain electron transfer in neuronal nitric-oxide synthase measured by pulse radiolysis. The Journal of biological chemistry 20011026
Validation of an HPLC method for the determination of urinary and plasma levels of N1-methylnicotinamide, an endogenous marker of renal cationic transport and plasma flow. Journal of pharmaceutical and biomedical analysis 20010101
Properties